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By Karsten Schrör

Written via a number one specialist on Aspirin-related study, this is often the main finished treatise at the pharmacological results and medical purposes of 1 of the main winning medicines ever.
The textual content is written with a large viewers in brain, and to be effortlessly comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised variation includes the newest result of scientific and pharmacological learn on Acetylsalicylic acid, addressing the a number of pharmacological houses of this recognized drug with a balanced view on their translation into medical perform, together with prevention from cardiovascular illnesses and colorectal cancer.

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1). Salicylate shows a peculiar physicochemical behavior because of the formation of a ring structure by hydrogen bridging. 8) but not with its m- and p-analogues. The o-position of the hydroxyl group facilitates the release of a proton with decreasing pH by increasing the mesomery of the resulting anion. 3). 1). The m- and p-hydroxy analogues of benzoic acid do not share these properties with salicylate and are biologically largely inactive. Structure–activity studies of 80 salicylate-type compounds for uncoupling oxidative phosphorylation in isolated mitochondria showed that the essential pharmacophore for this activity is a compound with a negatively charged (carboxyl) group at the o-position, that is, acetylsalicylate.

The Journal of Clinical Investigation, 56, 624–632. , Picot, D. M. (1995) The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase. Nature Structural Biology, 2, 637–643. , Henderson, B. et al. (1987) Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proceedings of the National Academy of Sciences of the United States of America, 84, 1417–1420. 31 Claria, J.

1945) Acetylsalicylic acid, a probable cause for secondary post-tonsillectomy hemorrhage. A preliminary report. Archives of Otolaryngology, Chicago, 42, 19–20. M. and MacKinnon, J. (1951) Aetiology of aspirin bleeding. The Lancet, 1, 569. Wising, P. (1952) Haematuria, hypoprothrombinemia and salicylate medication. Acta Medica Scandinavica, 141, 256. L. and Willie, A. (1955) Influence sur l’hemostase, de l’hypertension arterielle, des antivitamines K, de l’heparine et de l’acide acetyl salicylique.

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Acetylsalicylic Acid by Karsten Schrör


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