Get Acetylsalicylic Acid PDF

By Karsten Schrör

Written via a number one specialist on Aspirin-related study, this is often the main finished treatise at the pharmacological results and medical purposes of 1 of the main winning medicines ever.
The textual content is written with a large viewers in brain, and to be effortlessly comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised variation includes the newest result of scientific and pharmacological learn on Acetylsalicylic acid, addressing the a number of pharmacological houses of this recognized drug with a balanced view on their translation into medical perform, together with prevention from cardiovascular illnesses and colorectal cancer.

Show description

Read Online or Download Acetylsalicylic Acid PDF

Best cell biology books

New PDF release: Biochemistry of lipids, lipoproteins and membranes

Examine at the biochemistry and molecular biology of lipids and lipoproteins has skilled amazing progress within the final twenty years, rather with the conclusion that many various periods of lipids play primary roles in ailments reminiscent of middle illness, weight problems, diabetes, melanoma and neurodegenerative problems.

Download PDF by Bharat B. Aggarwal, Shishir Shishodia: Resveratrol in Health and Disease

Training evidenced-based drugs a few 25 centuries in the past, Hippocrates proclaimed "Let nutrients be thy drugs and medication be thy nutrients. " this recommendation parallels the typical American asserting, "You are what you eat," and is supported by way of a countrywide Institute of well-being suggestion to devour as many as 8 servings of vegetables and fruit day-by-day to avoid universal ailments.

J. P. J., H. P. S. (auth.), Dr. Jean-Pierre Jost, Dr.'s A Laboratory Guide to In Vitro Studies of Protein-DNA PDF

A security issues Many strategies defined right here contain a few dangers, reminiscent of excessive electric present and voltage, radioactivity and hugely poisonous chemical substances. it truly is totally crucial that the directions of apparatus brands be undefined, and that individual realization be paid to the neighborhood and federal protection rules.

The Science of Reconstructive Transplantation - download pdf or read online

This quantity offers a accomplished evaluate of the newest advances in uncomplicated and translational examine within the box of reconstructive transplantation and its power healing implications. Dr. Thomas E. Starzl and Dr. Raimund Margreiter, either pioneers within the box of transplantation, have written the foreword for the ebook.

Additional resources for Acetylsalicylic Acid

Example text

1). Salicylate shows a peculiar physicochemical behavior because of the formation of a ring structure by hydrogen bridging. 8) but not with its m- and p-analogues. The o-position of the hydroxyl group facilitates the release of a proton with decreasing pH by increasing the mesomery of the resulting anion. 3). 1). The m- and p-hydroxy analogues of benzoic acid do not share these properties with salicylate and are biologically largely inactive. Structure–activity studies of 80 salicylate-type compounds for uncoupling oxidative phosphorylation in isolated mitochondria showed that the essential pharmacophore for this activity is a compound with a negatively charged (carboxyl) group at the o-position, that is, acetylsalicylate.

The Journal of Clinical Investigation, 56, 624–632. , Picot, D. M. (1995) The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase. Nature Structural Biology, 2, 637–643. , Henderson, B. et al. (1987) Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proceedings of the National Academy of Sciences of the United States of America, 84, 1417–1420. 31 Claria, J.

1945) Acetylsalicylic acid, a probable cause for secondary post-tonsillectomy hemorrhage. A preliminary report. Archives of Otolaryngology, Chicago, 42, 19–20. M. and MacKinnon, J. (1951) Aetiology of aspirin bleeding. The Lancet, 1, 569. Wising, P. (1952) Haematuria, hypoprothrombinemia and salicylate medication. Acta Medica Scandinavica, 141, 256. L. and Willie, A. (1955) Influence sur l’hemostase, de l’hypertension arterielle, des antivitamines K, de l’heparine et de l’acide acetyl salicylique.

Download PDF sample

Acetylsalicylic Acid by Karsten Schrör

by George

Rated 4.21 of 5 – based on 23 votes