Read e-book online Automation in proteomics and genomics: an engineering PDF

By Gil Alterovitz, Visit Amazon's Roseann Benson Page, search results, Learn about Author Central, Roseann Benson, , Marco Ramoni

ISBN-10: 0470727233

ISBN-13: 9780470727232

Within the final decade DNA sequencing bills have reduced over a importance, principally as a result of expanding throughput by means of incremental advances in instruments, applied sciences and technique advancements. additional rate discounts during this and in comparable proteomics applied sciences are anticipated due to the improvement of recent high-throughput recommendations and the computational equipment had to learn facts generated.

Automation in Proteomics & Genomics: An Engineering Case-Based method describes the automation know-how at present within the components of research, layout, and integration, in addition to supplying simple biology ideas in the back of proteomics and genomics. The booklet additionally discusses the present technological obstacles that may be considered as an rising marketplace instead of a learn bottleneck. issues lined comprise:

  • molecular biology basics: from ‘blueprint’ (DNA) to ‘task checklist’ (RNA) to ‘molecular computing device’ (protein); proteomics equipment and applied sciences; modelling protein networks and interactions
  • research through automation: DNA sequencing; microarrays and different parallelization applied sciences ; protein characterization and id; protein interplay and gene regulatory networks
  • layout through automation: DNA synthesis; RNA through layout; construction protein libraries; man made networks
  • integration: a number of modalities; computational and experimental equipment; tendencies in automation for genomics and proteomics
  • new allowing applied sciences and destiny functions

Automation in Proteomics & Genomics: An Engineering Case-Based strategy is a vital advisor to the present functions and demanding situations of high-throughput research of genes and proteins for bioinformaticians, engineers, chemists, and biologists attracted to constructing a cross-discipline problem-solving established method of structures biology.

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Additional resources for Automation in proteomics and genomics: an engineering case-based approach

Sample text

Increased rates of mutation can introduce either stop codons or frameshifts; the frameshifts can be the result of either sequencing error or genomic mutation, especially for nonexpressed genes, and possibly be resolved with proteomics. 2 Seleno Proteins Selenocysteine (Sec) is a rare amino acid that significantly increases the enzymatic activity of a protein. A nucleotide triplet, UAG, which normally is interpreted as a stop codon, codes for Sec. In the presence of a cis-acting mRNA structure, called the selenocysteine insertion sequence (SECIS) element, this codon is recognized by selenocysteinyl tRNA, which integrates a Sec amino acid into the protein sequence.

1 Introduction Today, biologists are ‘awash’ with genomic sequence data, due in large part to the rapid acceleration in the generation of DNA sequences that has occurred during the race between public and private research institutes to sequence the human genome. In parallel with the large Human Genome Project effort, smaller genomes of other important model organisms have been sequenced. Subsequent projects have effectively utilized both the technological advances and the DNA sequencing infrastructure developed for the human and other organism’s genome projects.

Finding genes in prokaryotes is a relatively straightforward task because of the simple gene structure (uninterrupted open reading frames; ORFs) and high gene density, with almost the entire DNA used for coding; therefore, automated approaches to predict gene models in prokaryotes genomes is feasible. g. ‘gene deserts’ in human [3]). Despite the significant efforts made by many research groups, there are as yet no completely automated methods to predict gene models in eukaryotic genomes. Most of the eukaryotic gene predictors that have been developed and tuned for human or other higher eukaryote genomes are not applicable to another genome, and show low accuracy even between vertebrate genomes [4].

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Automation in proteomics and genomics: an engineering case-based approach by Gil Alterovitz, Visit Amazon's Roseann Benson Page, search results, Learn about Author Central, Roseann Benson, , Marco Ramoni


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