Download e-book for kindle: Bacterial Toxins: Tools in Cell Biology and Pharmacology by Klaus Aktories

By Klaus Aktories

ISBN-10: 3527308814

ISBN-13: 9783527308811

This can be a survey of good characterised and lately found bacterial protein pollutants. major investigators of the respective pollution evaluation a number of the molecular mechanisms of motion, starting from toxin-induced ADP-ribosylation as much as membrane perforation by way of pore-forming pollution. Thy additionally describe the implications on host body structure earlier than targeting power functions as telephone organic and pharmacological instruments for learn and scientific functions. unique descriptions of the technique contain the engineering and use of transformed and chimeric pollutants for larger functionality. a superb advent to toxin constitution and features, in addition to a necessary resource of technique for researchers in molecular biology, pharmacology and experimental medication.

Show description

Read Online or Download Bacterial Toxins: Tools in Cell Biology and Pharmacology PDF

Best microbiology books

Bacteria: A Very Short Introduction (Very Short - download pdf or read online

Micro organism shape a basic department of lifestyles. they're the oldest varieties of lifestyles and the main prolific of all residing organisms, inhabiting the whole lot of the Earth's floor, its ocean depths, or even such inhospitable locations as boiling scorching springs.

In this Very brief creation, bacteriologist Sebastian Amyes explores the character of micro organism, their beginning and evolution, micro organism within the surroundings, and micro organism and affliction. Amyes discusses the various significant infections as a result of bacteria-bacteria factors pneumonia, diphtheria, cholera, and plenty of different diseases-and indicates how those pathogens keep away from the defences of the human physique. however the e-book seems to be in any respect facets of micro organism, not only the detrimental aspect, stressing the main advantages of micro organism, that have been harnessed to maintain nutrition, get rid of waste and to supply compost for horticulture. certainly, lifestyles for guy and for plenty of animals will be most unlikely with no micro organism. Amyes additionally deals a look into the long run, describing how micro organism should be manipulated to accomplish initiatives that they earlier have been not able to accomplish and discussing the new building of a very man made bacterial telephone.

Download e-book for kindle: Prescott, Harley, and Klein's Microbiology (7th Ed.) by Joanne M. Willey, Linda Sherwood, Christopher J. Woolverton

The writer staff of Prescott’s Microbiology maintains the culture of previous versions through delivering a balanced, complete creation to all significant components of microbiology. due to this stability, Microbiology is acceptable for microbiology majors and combined majors classes. the recent authors have thinking about clarity, paintings, and the mixing of a number of key subject matters (including evolution, ecology and variety) through the textual content, making an already stronger textual content even higher.

Download e-book for iPad: Understanding pathogen behaviour : virulence, stress by Mansel Griffiths

Pathogens reply dynamically to their surroundings. realizing their habit is important for 2 very important purposes: as a result of rising proof of elevated pathogen resistance to verified sanitation and renovation thoughts and thanks to the elevated use of minimum processing applied sciences, that are probably extra at risk of the improvement of resistance.

Extra resources for Bacterial Toxins: Tools in Cell Biology and Pharmacology

Example text

130:185-202. Fishrnan PH (1982): Role of membrane gangliosides in the binding and action of bacterial toxins. In J. Membr. Biol. 69:85-97. Fontana MR, Manetti R, Giannelli V, et a/. (1995): Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit. In Infect. Imrnun. 63:2356-2360. Gill DM, Coburn J (1987): ADP-ribosylation by cholera toxin: Functional analysis of a cellular system that stimulates the enzymatic activity of cholera toxin fragment A,.

0 Chapman & Hall, Weinheim, 1997. , 1995), has helped to define further the function of ARF in cells. Investigations into the role of ARFs in these processes have employed recombinant wild-type and mutant ARF constructs. Thus, the assays discussed here have become commonly used to measure native ARFs, and to assess the integrity of recombinant proteins and the effects of mutations on their activity. , 1981). Pure CT, as iudged by isoelectric focusing, can also be obtained using Mono Q FPLC (Spangler and Westbrook, 1989).

Holmgren J, Czerkinsky C, Lycke N, et a/. (1994): Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adiuvant. In Am. J. Fop. Med. Hyg. 50:42-54. Jobling MG, Holmes RK (1992):Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras. In Infect. Immun. 60:4915-4924. Johnson GL, Kaslow HR, Bourne HR (1978):Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.

Download PDF sample

Bacterial Toxins: Tools in Cell Biology and Pharmacology by Klaus Aktories

by Kevin

Rated 4.89 of 5 – based on 19 votes