By Klaus Aktories
This can be a survey of good characterised and lately found bacterial protein pollutants. major investigators of the respective pollution evaluation a number of the molecular mechanisms of motion, starting from toxin-induced ADP-ribosylation as much as membrane perforation by way of pore-forming pollution. Thy additionally describe the implications on host body structure earlier than targeting power functions as telephone organic and pharmacological instruments for learn and scientific functions. unique descriptions of the technique contain the engineering and use of transformed and chimeric pollutants for larger functionality. a superb advent to toxin constitution and features, in addition to a necessary resource of technique for researchers in molecular biology, pharmacology and experimental medication.
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Extra resources for Bacterial Toxins: Tools in Cell Biology and Pharmacology
130:185-202. Fishrnan PH (1982): Role of membrane gangliosides in the binding and action of bacterial toxins. In J. Membr. Biol. 69:85-97. Fontana MR, Manetti R, Giannelli V, et a/. (1995): Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit. In Infect. Imrnun. 63:2356-2360. Gill DM, Coburn J (1987): ADP-ribosylation by cholera toxin: Functional analysis of a cellular system that stimulates the enzymatic activity of cholera toxin fragment A,.
0 Chapman & Hall, Weinheim, 1997. , 1995), has helped to define further the function of ARF in cells. Investigations into the role of ARFs in these processes have employed recombinant wild-type and mutant ARF constructs. Thus, the assays discussed here have become commonly used to measure native ARFs, and to assess the integrity of recombinant proteins and the effects of mutations on their activity. , 1981). Pure CT, as iudged by isoelectric focusing, can also be obtained using Mono Q FPLC (Spangler and Westbrook, 1989).
Holmgren J, Czerkinsky C, Lycke N, et a/. (1994): Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adiuvant. In Am. J. Fop. Med. Hyg. 50:42-54. Jobling MG, Holmes RK (1992):Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras. In Infect. Immun. 60:4915-4924. Johnson GL, Kaslow HR, Bourne HR (1978):Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.
Bacterial Toxins: Tools in Cell Biology and Pharmacology by Klaus Aktories