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ISBN-10: 3131534311

ISBN-13: 9783131534316

ISBN-10: 3131666412

ISBN-13: 9783131666413

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Extra resources for Biochemie. 3

Sample text

Da lg M- Mol ek ül e Pentamere si nd . besitzen Der men schliche Körper kann spe zi fi sche Antikörper gegen mehrere Millionen verschiedene Antige ne bilden. doch nicht jeder Antikörper hat sein eigenes Gen. Die Antikörpervielfalt mu ss al so auf andere Weise entstehen . Sie wird durch 2 Me chani smen gewährleistet: • somatische Rekombination (Gen- Rearrangement): während der Entwicklung der B-Zellen im Knoche nmark, • somatische Mutation: in den variablen Be reich e n de r lmmun globulingene. ~ somatische Rekombination.

IFNy, TN Fa Freisetzung von IL-4. 5, 6, 10,13 Aktivierung von B-Zellen, TcZellen. Tw Zellen, APZ ( antigenpräsentierende Zellen} Umwand lung von B-Zellen, T-Suppressorzellen? S. 29). Bei dieser sog. MHC-Restriktion spielen die beiden Molekü le CD4 und CDS eine wichtige Rolle, di e sich ebenfalls auf d er T-Zeli-Oberfläche befinde n. Differenzierung der T-Zellen Die in den Thymus ei ngew an derten Stammzellen reifen zu TZellen. Weniger als 5 % der ursprüng lichen Zellen überl eben diesen Reifungsprozess.

Im Gegensatz z u den zytotoxischen T-Zellen benötigen NI

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Biochemie. 3


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